徐冬旸

-基本信息

徐冬旸|生命科学博士

副教授,硕士生导师(招收药学专业学硕,欢迎邮件咨询)

邮箱:xudongyang@hqu.edu.cn

地址:福建省厦门市集美区集美大道668号华侨大学厦门校区泛华科技楼B201




-研究方向

方向一:功能基因组学,基于CRISPR/Cas13等反向遗传学技术和慢病毒插入突变文库筛选等正向遗传学方法,结合高通量测序和生物信息学分析,对基因组中的长链非编码RNA及参与抗癌药物耐药作用的新基因和新转录本进行功能鉴定。

方向二:基因组学新方法新技术开发,通过基因组特征性序列标记和捕获,结合高通量测序技术,开发新的基因组学研究方法和技术,主要研究对象包括全基因组范围内的DNA损伤(如单链和双链DNA断裂)、基因组中的单链DNA区域,以及线粒体DNA复制起点等。


-教育经历

2014/10-2017/09,北海道大学,博士

2010/09-2013/06,华南理工大学,硕士

2006/09-2010/06,北京林业大学,学士


-科研与学术工作经历

2017/12-今,华侨大学,bwin必赢,讲师/副教授



-课程教学

1、 分子肿瘤学(中文及全英文课程,本科生课程)

2、 工业及药物生物技术(全英文课程,本科生课程)

3、 生物医学工程进展(硕士生课程)

4、 科技文献写作专题(硕士生课程)


-参与或主持科研项目

1、国家自然科学基金,青年科学基金项目,24万元,主持

2、福建省自然科学基金面上项目,10万元,主持

3、华侨大学中青年教师科技创新资助计划,40万元,主持

4、华侨大学高层次人才科研启动费项目,12万元,主持

5、福建省自然科学基金重点项目,30万元,参与

6、国家自然科学基金,面上项目,58万元,参与


-发表文章

1. Dongyang Xu#, Lu Tang#, Junjun Zhou, Fang Wang, Huifen Cao, Yu Huang, Philipp Kapranov*, Evidence for widespread existence of functional novel and non-canonical human transcripts. BMC Biology, 2023, 21: 271. (中科院一区Top)

2. Dongyang Xu, Lu Tang, Philipp Kapranov*, Complexities of mammalian transcriptome revealed by targeted RNA enrichment techniques. Trends in Genetics, 2023, 39: 329-333. (中科院二区Top)

3. Fan Gao, Ye Cai, Philipp Kapranov*, Dongyang Xu*, Reverse-genetics studies of lncRNAs—what we have learnt and paths forward, Genome Biology, 2020, 21: 93. (中科院一区Top)

4. Huifen Cao#, Dongyang Xu#, Ye Cai#, Xueer Han#, Lu Tang, Fan Gao, Yao Qi, Dingding Cai, Huifang Wang, Maxim Ri, Denis Antonets, Yuri Vyatkin, Yue Chen, Xiang You, Fang Wang, Estelle Nicolas, Philipp Kapranov*, Very long intergenic non-coding (vlinc) RNAs directly regulate multiple genes in cis and trans, BMC Biology, 2021, 19: 108. (Co-first author) (中科院一区Top)

5. Dongyang Xu, Yu Huang, Lingcong Luo, Lu Tang, Meng Lu, Huifen Cao, Fang Wang, Yong Diao, Liudmila Lyubchenko, Philipp Kapranov*, Genome-wide profiling of endogenous single-stranded DNA using the SSiNGLe-P1 method. International Journal of Molecular Sciences, 2023, 24, 12062. (中科院二区)

6. Dongyang Xu#, Lingcong Luo#, Yu Huang, Meng Lu, Lu Tang, Yong Diao, Philipp Kapranov*, Dynamic patterns of mammalian mitochondrial DNA replication uncovered using SSiNGLe-5'ES. International Journal of Molecular Sciences, 2023, 24, 9711. (中科院二区)

7. Dongyang Xu#, Ye Cai#, Lu Tang, Xueer Han, Fan Gao, Huifen Cao, Fei Qi, Philipp Kapranov*, A CRISPR/Cas13-based approach demonstrates biological relevance of vlinc class of long non-coding RNAs in anticancer drug response, Scientific Reports, 2020, 10: 1794. (中科院二区)

8. Dongyang Xu, Jiahang Miao, Emi Yumoto, Takao Yokota, Masashi Asahina, Masaaki Watahiki*, YUCCA9-mediated auxin biosynthesis and polar auxin transport synergistically regulate regeneration of root systems following root cutting, Plant and Cell Physiology, 2017, 58: 1710-1723. (Cover paper) (中科院二区)

9. Dongyang Xu, Qing Nie, Wenyan Wang, Lei Shi, He Yan*, Characterization of a transferable bcrABC and cadAC genes-harboring plasmid in Listeria monocytogenes strain isolated from food products of animal origin, International Journal of Food Microbiology, 2016, 217: 117-122. (中科院一区Top)

10. Dongyang Xu, Yanli Li, M. Shamim Hasan Zahid, Shinji Yamasaki, Lei Shi, Jianrong Li*, He Yan*, Benzalkonium chloride and heavy-metal tolerance in Listeria monocytogenes from retail foods, International Journal of Food Microbiology, 2014, 190: 24-30. (中科院一区Top)

11. Dongyang Xu, Yan Deng, Rongdong Fan, Lei Shi, Jianshan Bai*, He Yan*, Coresistance to benzalkonium chloride disinfectant and heavy metal ions in Listeria monocytogenes and Listeria innocua swine isolates from China, Foodborne Pathogens and Disease, 2019, 16: 696-703. (中科院二区)

12. Yang Zhang#, Dongyang Xu#, Lei Shi, Rujian Cai, Chunling Li, He Yan*, Association between agar type, virulence factors, biofilm formation and antibiotic resistance of Staphylococcus aureus isolates from pork, Frontiers in Microbiology, 2018, 9: 1876. (Co-first author) (中科院二区Top)

13. Yue Chen#, Fei Qi#*, Fan Gao, Huifen Cao, Dongyang Xu, Kourosh Salehi-Ashtiani and Philipp Kapranov*, Hovlinc is a recently evolved class of ribozyme found in human lncRNA, Nature Chemical Biology, 2021, 17: 601-607. (中科院一区Top)

14. Huifen Cao#, Lorena Salazar-Garcia#, Fan Gao, Thor Wahlestedt, Chunlin Wu, Xueer Han, Ye Cai, Dongyang Xu, Fang Wang, Lu Tang, Natalie Ricciardi, Dingding Cai, Huifang Wang, Mario P.S. Chin, James A. Timmons, Claes Wahlestedt*, Philipp Kapranov*, Novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cells, Nature Communications, 2019, 10: 5799. (中科院一区Top)

15. Fang Wang#, Huifen Cao#, Qiu Xia#, Ziheng Liu, Ming Wang, Fan Gao, Dongyang Xu, Bolin Deng, Yong Diao, Philipp Kapranov*, Lessons from discovery of true ADAR RNA editing sites in a human cell line, BMC Biology, 2023, 21: 160. (中科院一区Top)

16. Huifen Cao, Yufei Zhang, Ye Cai, Lu Tang, Fan Gao, Dongyang Xu, Philipp Kapranov*, Hotspots of single-strand DNA "breakome" are enriched at transcriptional start sites of genes, Frontiers in Molecular Biosciences, 2022, 9: 895795. (中科院三区)

17. He Yan, Dongyang Xu, Hecheng Meng, Lei Shi, Lin Li*, Food poisoning by clenbuterol in China, Quality Assurance and Safety of Crops & Foods, 2014, 7: 27-35. (中科院三区)



-授权发明专利

一种检测DNA中的单链断裂的方法,ZL 201910837092.1,2022,排名第5。


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