解丽娟

-基本信息

解丽娟 联系电话:13055610298 邮箱:xielijuan@hqu.edu.cn

bwin必赢副研究员

本科毕业于华东理工大学化学制药专业

研究生(硕博)就读于大连理工大学精细化工国家重点实验室应用化学专业

先后在香港中文大学和美国德州大学奥斯丁分校作访问学者

工作经历:

· 2009.5-现今  bwin必赢  历任助理研究员、副研究员

· 2014.3-2015.3 德州大学奥斯汀分校 化学生物学系 访问学者

· 2010.10-2011.4 香港中文大学 化学系  访问学者  

· 1993.7- 2002.7 抚顺石油化工研究院 历任实习员、助理工程师和工程师



-研究方向

1. 抗肿瘤药物 针对乳腺癌、白血病等恶性肿瘤的化合物的设计、合成及生物活性研究

2. 细胞器靶向荧光探针研究

-主持课题

                 · 萘酰亚胺类PARP抑制剂的研究。厦门市自然科学基金,项目编号3502Z202373048

· 抑制白血病细胞生长的萘酰亚胺类化合物的研究。泉州市科技计划项目,项目编号2019C033R

· 氨萘非特增效、减毒新方法的研究。福建省科技厅社会发展重点项目,项目编号2013Y0066

· 聚乙二醇修饰的氨萘非特作为抗肿瘤药物的研究。侨办课题,专案编号11J0277

· 对神经细胞内钙离子和一氧化氮进行同步检测的荧光探针。大连理工大学精细化工国家重点实验室开放课题,项目编号KF0901

· 含有18-萘酰亚胺单体的聚乙烯亚胺类非病毒基因载体的研究。华南肿瘤学国家重点实验室开放课题,2009.8-2011.7

· 5-位芳香基团取代的萘酰亚胺类化 合物的设计、合成及生物活性研究。校级课题,专案编号09Y0142


-发表文章及专利

1.发表文章:

1.1Chuanhao Liu,  Lin Zhou, Ying Zheng, Huizi Man, Zhiwei Ye, Xinfu Zhang,  Lijuan Xie*, Yi Xiao*.A Golgi-targeted viscosity rotor for monitoring early alcohol-induced liver injury. Chem. Commun., 2022,58, 10052-10055. DOI: 10.1039/d2cc04069g

1.2 Chuanhao Liu, Lin Zhou, Lijuan Xie*, Ying Zheng, Huizi Man, and Yi Xiao*. Forthrightly Monitoring Ferroptosis Induced by Endoplasmic Reticulum Stresses (ERS) through Fluorescence Lifetime Imaging of Microviscosity Increases with a Specific Rotor. Chinese Chemical Letters. 2022, 33, 2537–2540. https://doi.org/10.1016/j.cclet.2021.11.082

1.3 Zhou lin, Xie Lijuan*, Liu Chuanhao, Xiao Yi*. New trends of molecular probes based on the fluorophore 4-amino-1,8-naphthalimide. Chinese Chemical Letters.2019, 30(10), 1799-1808.

1.4 Jinfeng Yu, Hui Bian, Huizi Man, Ning Li, Lijuan Xie,* Yi Xiao,**Two–photon excitable red fluorophores for imaging living cells. Dyes and Pigments, 2018, 149,851–857

1.5 解丽娟*,陈卓.类呋喃香豆素的合成与DNA的结合及细胞毒性研究.光谱学与光谱分析,2014,34(11),3051-3055 .SCI收录

1.6 解丽娟*,李建民. 7-二乙胺基-3-(2’-吡啶)香豆素的新用途:溶酶体荧光探针.发光学报, 2013, 34(11), 1538-1543.EI收录

1.7 Yinghui Chen, Jianzhang Zhao, Lijuan Xie, Huimin Guo, Qiuting Li. Thienyl-substituted BODIPYs with strong visible light-absorption and long-lived triplet excited states as organic triplet sensitizers for triplet–triplet annihilation upconversion. RSC Advances., 2012, 2, 3942-3953.

1.8 Yinghui Chen, Jianzhang Zhao, Huimin Guo, Lijuan Xie. Geometry Relaxation-Induced Large Stokes Shift in Red-Emitting Borondipyrromethenes (BODIPY) and Applications in Fluorescent Thiol Probes. The Journal of Organic Chemistry, 2012, 77 (5), 2192–2206.

1.9 Lijuan Xie*, Yinghui Chen, Wenting Wu, Huimin Guo, Jianzhang Zhao, Xuerong Yu. Fluorescent coumarin derivatives with large stokes shift, dual emission and solid state luminescent properties: An experimental and theoretical study. Dyes and Pigments, 2012, 92, 1361-1369.

1.10 Xu Ke; Liang Xin; Wang Fang; Xie Lijuan; Xu Yufang; Liu Jianwen; Qian Xuhong. Induction of G(2)/M phase arrest and apoptosis by potent antitumor APCA in human cervix carcinoma cells. Anti-Cancer Drugs, 2011, 22 (9), 875-885.

1.11 Lijuan Xie, Jingnan Cui, Xuhong Qian, Yufang Xu, Jianwen Liu, R.A.Xu. 5-Non-amino aromatic substituted naphthalimides as potential antitumor agents: Synthesis via Suzuki reaction, antiproliferative activity, and DNA-binding behavior. Bioorganic & Medicinal Chemistry, 2011; 19 (2), 961-967.

1.12 Li-juanXie*, 5-Butylamino-2-[2-(dimethylamino)-ethyl]-1H-benz[de] isoquinoline-1,3(2H) -dione. Acta Crystallographica Section E, 2010, E66, O1454-U1788

1.13 Lijuan Xie,Yi Xiao, Fang Wang, Jianwen Liu, Yufang Xu, Xuhong Qian, Jingnan Cui. Rong Zhang. Novel acenaphtho[1,2-b]pyrrole-carboxylic acid family: Synthesis, cytotoxicity, DNA-binding and cell cycle evaluation. Bioorganic & Medicinal Chemistry, 2009, 17, 7615–7621.

1.14 Kewei Wang, Jingnan Cui, Lijuan Xie, Xuhong Qian. Design, synthesis, and Evaluation of Unsymmetrical Difluoro-Boron Complexes with Imidazoline as Potential Fungicides. Heteroatom Chemistry, 2009, 20 (7), 418-424.

1.15 Lijuan Xie, Yufang Xu, Fang Wang, Jianwen Liu, Xuhong Qian, Jingnan Cui. Synthesis of new amonafide analogues via coupling reaction and their cytotoxic evaluation and DNA-binding studies. Bioorganic & Medicinal Chemistry, 2009, 16, 804-810.

1.16 Lijuan Xie, Xuhong Qian, Jingnan Cui, Yi Xiao, Kewei Wang, Peichun Wu, Liying Cong. Novel angular furoquinolinones bearing flexible chain as antitumor agent: Design, synthesis, cytotoxic evaluation, and DNA-binding studies. Bioorganic & Medicinal Chemistry, 2008, 16, 8713-8718.

1.17解丽娟,张艳丽,王崇晖.十三碳二元酸的精制方法. 精细与专用化学品, 2002,20,13-14.

1.18王崇辉,张艳丽,宋喜军,解丽娟.大环麝香香料麝香-T的工业化合成技术. 精细与专用化学品 , 2001, 23, 15-17.

1.19张艳丽,宋喜军,解丽娟,高大成.混料设计及调优软件在热熔胶配方实验中的应用. 中国胶粘剂 , 2002, 3, 1-3.

1.20 王崇晖,张艳丽,宋喜军,解丽娟, 麝香-T的工业化合成技术研究;2002年中国香料香精学术研讨会  20020316, 上海

授权专利:

2.1 酰亚胺位或4-位取代的1,8-萘酰亚胺衍生物作为PARP抑制剂的用途”。CN201410072552.3

2.2 一种萘酰亚胺双光子荧光染料、其制备方法和应用”。CN201511000130.6

2.3 “长碳链尼龙热熔胶及其合成方法” 专利号:02144534.6

2.4 聚酰胺热熔胶配方的确定方法” 专利号:02109667.8

2.5 一种大环酯类麝香化合物的制造方法” 专利号:01133369.3

2.6 一种大环内酯化合物的生产工艺” 专利号:01133365.0

2.7 控制聚酰胺热熔胶熔融指数的方法” 专利号:01133360.X

2.8 一种制备聚酰胺热熔胶的方法” 专利号:01133363.4

2.9 一种长链尼龙盐的制造方法” 专利号:00110713.5

2.10 长链二羧酸及其酯的制备方法” 专利号:00123140.5

2.11 “一种从发酵液中提到精制α、ω-长链二羧酸的方法” 专利号:99113296.3

2.12 “一种大环双酯类麝香化合物的提纯精制方法” 专利号:99113306.4

2.13 “共聚酰胺热熔胶及其制备方法” 专利号:98121049.X


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